RAF Typhoon FGR4s have operated alongside French aircraft in a combined operation against an hidden munitions depot in Syria used by the IS group, according to the British defence ministry.
The facility, located using intelligence, was assessed as storing arms and explosives, the release indicated, and was located in mountains just to the north of the ancient city of Palmyra in Syria's central region.
"The RAF jets utilized precision-guided Paveway IV munitions to strike a series of approach shafts down to the depot... initial indications are that the target was engaged successfully," the MoD said.
There was no indication of any civilian casualties in the operation conducted Saturday night and all the aircraft made a safe return, the MoD added.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
The Islamic State group - alternatively referred to as Daesh - established jihadist rule over significant areas in Syria and Iraq before its territorial defeat in 2019.
"This action demonstrates our UK leadership, and resolve to work closely with our partners, to stamp out any re-emergence of Daesh and their dangerous and violent ideologies in the Middle East," the British Defence Secretary John Healey said.
RAF aircraft have performed overwatch operations over Syria to "deter any attempted comeback" of IS subsequent to its routing at the climactic battle in Baghuz in 2019, the MoD reported.
"I want to thank the personnel of the UK armed forces who took part in this mission for their expertise and their bravery," Healey added. "They were part of thousands of UK service members on duty over the festive period. This action, to take out militants who pose a risk to our way of life, demonstrates how our armed forces are prepared to act, all year round, protecting the UK at home and powerful internationally."
In December, the US military executed what it called a "massive strike" against Daesh sites in Syria, following an assault killed two US servicemembers and a local interpreter in the Palmyra area.
The United Nations estimates IS still maintains an estimated 5,000 to 7,000 combatants in both countries.
